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    Zudena has the following active ingredient: Udenafil. Zudena (Udenafil) is a therapeutic agent hypothesized to improve erectile dysfunction through interaction with the phosphodiesterase type 5 (PDE5) enzyme. How to use
    – The joint application of Udenafil (30 mg / kg orally) and nitroglycerin (2.5 mg / kg once, w / w) did not reveal any effect on the pharmacokinetics of Udenafil in experimental studies, but the simultaneous use of nitroglycerin and of Udenafil is not recommended because of possible reduce blood pressure.
    List of those who must take Zudena with extra caution: Patients with uncontrolled hypertension, Patients with hereditary degenerative diseases of the retina (including retinitis pigmentosa, proliferative diabetic retinopathy); Patients who have undergone over the last 6 months of stroke, myocardial infarction or coronary artery bypass grafting;
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    Warnings/Precautions Sexual activity is a potential risk for patients with cardiovascular disease, so treatment of erectile dysfunction, including using of Udenafil, should not hold for men with heart disease, in which sexual activity is not recommended.
    Patients with obstruction of blood outflow from the left ventricle (aortic stenosis) may be more sensitive to the action of vasodilators, including inhibitors of PDE. Despite the lack of clinical trials of cases of prolonged erection (longer than 4 hours) and priapism (painful erections lasting more than 6 h), such phenomena are peculiar to this class of drugs. In the event of an erection lasting more than 4 hours (regardless of pain), patients should immediately seek medical help. In the absence of timely treatment of priapism can lead to irreversible damage to the erectile tissue and erectile function.

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